New Evidence Shows a Surprising Cause of Weight Gain and Obesity

What the rich and famous have known for decades has recently been confirmed by a team at Baylor College of Medicine. They have confirmed the reason why we gain weight as we age (1). This, along with other recent studies, demonstrate that a primary cause of age related weight gain and even obesity is as a result of the excessive buildup of toxins, also known as free radicals. These free radicals are the result of over consuming carbohydrates and sugars (2). The toxicity and unprocessed free radicals (also known as oxidative stress) create a dysfunction in the human body where the metabolism malfunctions, using fewer calories while storing more fat tissue, increasing the speed of weight gain while also increasing the difficulty of weight loss (2). This causes frustration for many due to a lack of results following modifications to lifestyle and diet, or even adding exercise.

For many people, myself included, the battle of the bulge has been a lifetime struggle that until recently I have been fighting unsuccessfully. What I’ve discovered is that the elaborate biochemical process controlling how much fat we store, how much we use, and how hungry we are can break down under high levels of toxicity, making it easier to retain fat (2). When we attempt to lose this fat through modifying our diets and adding physical activity, our best efforts are met with disappointment because the natural systems in our bodies aren’t performing optimally anymore due to the unnaturally high level of toxins.

This abnormally high state of unprocessed toxins is also reinforced over time by chronic consumption of artificial sweeteners, along with weight loss products and pills which add more free radicals, causing even more oxidative stress. These common habits designed to help reduce body weight actually make the problem worse, causing additional fat storage.

Fortunately, what I can share with you today is that I’ve discovered the keys to unlocking this cycle. Below is my story, detailing how the body’s metabolism and fat storage are impacted by levels of oxidative stress within the body (2), along with free radicals and unchecked toxins that increase this state of oxidative stress.

How Nano Glutathione Changed My Life

I initially began taking Nano-Glutathione on the recommendation of a friend of mine that had experienced some incredible results. After doing a bit of research on glutathione, it became clear that it was a critically important part of every cell in the body. Glutathione has been featured in over 90,000 research studies, and low glutathione has been linked to a long list of diseases including heart disease, diabetes, brain diseases like Alzheimer’s and Parkinson’s, obesity, various autoimmune conditions, Autism and ADHD, osteoporosis and more (3-11).

What was even more fascinating is that glutathione plays a central and very important role in a complex set of hormones responsible for metabolism, storage of fat, and appetite which I’ll cover shortly – but first my remarkable story.

After just a few short days of starting Nano-Glutathione, I immediately saw a difference. I had a much easier time getting up in the morning and I didn’t have to drink coffee all afternoon to avoid those post lunch crashes. After about a week or so, it felt as if someone had turned on a switch inside me that had been off for so long I’d forgotten it was even there. I was also noticeably less puffy (probably due to water retention) and my skin complexion improved remarkably.

I’ve been regularly working out for years, but recently in spite of my regular exercise I had started to slowly gain a bit of extra weight around my middle. I don’t think most people would call me fat, but I wouldn’t say I’m really fit or thin either. Even though I had gone through stints of increased physical activity, I didn’t really see any improvements. I kind of gave up hope, accepting that carrying a few extra pounds was just part of aging.

I maintained the same exercise and diet routine during the first few weeks that I was taking Nano-Glutathione. I’d classify my normal diet as average. I didn’t eat too many unhealthy foods, but I wasn’t only eating lean protein and vegetables either. I wasn’t in the habit of weighing myself too often and didn’t pay too much attention to my body as initially I wasn’t aware of the role that glutathione plays in the body’s metabolism. One morning much to my surprise and delight, my boyfriend looked at me and said, “Are you doing something different? You look great!” This is when I initially started getting curious about what else glutathione did in the body and began my research.

After pouring through google for hours, reading through countless articles and studies, I realized how fundamental and important the role is that glutathione has within the metabolism. I was so excited about what I’d discovered that I wrote up my notes on how I thought these systems work and sent them to the company that makes Nano-Glutathione. They were so impressed, they asked me to share my story and my notes. You’ve just read my story. I hope my explanation of how critical this molecule is to cellular respiration and the metabolism helps you as much as it has me.

DISCLAIMER: While the results presented are factual and there is strong research on the connection between insulin resistance, leptin, inflammation, oxidative stress, and low glutathione levels supporting the idea that supplementing glutathione levels may help those with low glutathione levels, individual results can and will vary and the results indicated above may not be typical.

Glutathione, Hormones, and Metabolism

The actual process of how free radicals, toxins, and oxidative stress cause additional fat storage and prevent weight loss are complicated. Recent research has begun to shed some light on how this complex system functions. The primary players are insulin, leptin, oxidative stress, and inflammation.

Insulin is a hormone manufactured in the pancreas. Among its duties in the body is the regulation of blood sugar. It also assists by regulating various hormones in the body. Insulin is the molecule that allows cells to absorb glucose, which comes from sugar and carbohydrates in the food we eat (chips, pastas, breads, desserts, etc). Once the glucose is absorbed into the cell, it is either used as energy or converted into fat. The amount of insulin produced by the body is directly linked to the amount of sugars and carbohydrates a person consumes.

Leptin is a hormone produced within the fat cells. One of leptin’s primary functions is to signal the brain, helping the brain understand how much fat is already stored, which then allows the brain to regulate hunger levels. This tells us whether we should eat more or not. As the levels of fat in the body increase, so do the levels of leptin. Increased insulin levels also result in the production of additional leptin.

As leptin levels in the body increase, so do levels of free radicals and oxidative stress, which in turn increase levels of inflammation. All of this is a normal part of cellular respiration and the metabolic process. As we discussed earlier though, the body was only designed to handle so much oxidative stress, as there is a maximum glutathione production capacity within each person. Additionally, this maximum amount decreases steadily as we age, and it is also reduced as levels of oxidative stress increase.

Now here is where things really start to fall apart. During the process of over-consuming food, and especially sugar and carbohydrates, a constant state of inflammation follows from the increased levels of oxidative stress. This starts to create insulin resistance because the insulin isn’t able to easily pass through the walls of a cell when it is inflamed. The body then in turn creates more insulin to overcome the insulin resistance, which then creates more leptin, which increases oxidative stress and inflammation, which starts a downward spiral.

In addition, the brain starts to become desensitized to the constant flow of leptin. If you recall, leptin is what controls hunger levels. So when this normal process breaks, the brain continues to tell us we’re hungry when we really don’t need anymore food. And to make matters even worse, since the body’s glutathione stores are being exhausted by this metabolic process, more and more toxins and free radicals from other sources start to backup, pushing the body into a state of rapid weight gain, metabolic disorders, diabetes, and eventually a long list of other diseases (15).

What I’m sure most of you are wondering is: how do you stop this vicious cycle? The first step is to help the body reduce inflammation and oxidative stress. This can be done in part by adjusting diet (reducing or eliminating sugars, carbohydrates, processed foods, and preservatives), along with adding mild to moderate exercise. In my case, I had already made these changes, but my body was still not responding because I had a buildup of cellular inflammation and oxidative stress. So, when I added Nano-Glutathione, my body got immediate assistance in clearing the oxidative stress buildup. This helped my body and metabolism function optimally which produced my remarkable results.

What It All Means

I realize all of this is complicated and a bit difficult to follow. These complex relationships between hormones have just recently started to be understood by the experts. One thing in all of this is clear though. The connection between fat storage and the metabolism is not just a question of how much you eat and how much you exercise. The increase in inflammation caused by oxidative stress and low glutathione can slow the amount of calories burned, increasing how many calories are stored as fat, making weight gain easier and weight loss much more difficult.

Increasing glutathione levels has been shown to combat oxidative stress, which reduces inflammation and also optimizes the body’s metabolism (12). This was so crucial for someone like me who was already doing the right things with my diet and fitness routine, but just wasn’t seeing the results I was looking for due to my high levels of oxidative stress and low glutathione.

What is Glutathione?

Glutathione is often referred to as the “miracle molecule” or “master antioxidant.” It is the primary cellular antioxidant and intracellular detoxifier in the body.

One of the primary reasons more people aren’t talking about glutathione is that traditional oral supplements have been shown in various studies to be ineffective, as the glutathione molecule cannot survive the hostile acids within the stomach (13). The preferred effective method of supplementing glutathione was to receive painful and expensive IV treatments (over $500 for each treatment) in a doctor’s office or supplementing with very moderately effective glutathione precursors such as NAC, alpha lipoic acid (ALA), whey protein, or selenium.

Studies show that Glutathione levels in our cells begin a continuous decline of about 1% a year from about age 20 onward (14). This comes as little surprise when you think about your most vibrant, healthy years being those in your late teens and early 20s.

Decreased glutathione is a significant risk factor to the following list of chronic diseases:

Obesity, diabetes, heart disease, cancer, Alzheimer’s, Parkinson’s, premature aging, Autism, eczema and psoriasis, rheumatoid arthritis, autoimmune diseases, osteoporosis, seizures and more

Why is Nano Glutathione Different?

Nano Glutathione is able to bypass the hostile stomach and gastrointestinal tract because it absorbs directly through the mucous membranes of the mouth. This is due to the cutting edge technology used to produce Nano Glutathione, which reduces each particle size to 1/20,000 of a normal glutathione particle, allowing nearly 60% of each Nano Glutathione dose to absorb directly into the bloodstream within seconds (15). This makes Nano Glutathione one of the most effective ways to supplement glutathione available. By comparison, a study by Bastyr University Research Institute and the University of Washington showed traditional oral glutathione was almost completely ineffective raising glutathione levels or reducing oxidative stress (13).

Supplementing With Nano Glutathione

The following accounts along with many more can be seen in the product reviews in the company’s Facebook page.

*Individual user experience and product reviews may not be typical. Results can and will vary

Try it For Yourself

Crystal, Nicole, Rebecca, and I all received our Nano Glutathione direct from the manufacturer Nanoceutical Solutions. Nanoceutical Solutions manufactures their Glutathione in San Antonio, Texas in an FDA registered facility, and they manufacture all their supplements with pharmaceutical grade ingredients. At the time of writing, the company also carries an A+ rating with the BBB, and 4.8 stars out of 5 on Facebook. The company stands behind their products with a 90 day guarantee, and they are offering a special incentive to new customers through this page which can be claimed by following the link below. And if your results are as remarkable as mine were, please come back and let me or the company know. I’d love to know my story helped as many others as possible.

* Offer only valid for new customers. Participation may require joining a subscription program in which you will be billed until you cancel. Valid only on 3 bottle supply. Not valid on single month supply. See the terms and conditions on the website for details.

Representations regarding the efficacy and safety of Nano Glutathione have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. It is recommended that users follow a strict diet and exercise regimen to achieve weight loss results. These products are not intended to diagnose, prevent, treat, or cure any disease. Click below to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of glutathione based on the expertise of relevant professionals.

 

References

  1. Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione Dan Nguyen-Susan Samson-Vasumathi Reddy-Erica Gonzalez-Rajagopal Sekhar – http://onlinelibrary.wiley.com/doi/10.1111/acel.12073/abstract
  2. Effect of Leptin and Oxidative Stress in the Blood of Obese Individuals Shaimaa Ahmed-Firas Maher-Nazar Naji – https://www.omicsonline.org/open-access/effect-of-leptin-and-oxidative-stress-in-the-blood-of-obese-individuals-2161-1009-1000288.php?aid=80393&view=mobile
  3. Oxidative Stress and Obesity: The Chicken or the Egg? Annayya Aroor-Vincent DeMarco – http://diabetes.diabetesjournals.org/content/63/7/2216
  4. Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochondrial Fuel Oxidation, Insulin Sensitivity, and Body Composition in Older HIV-Infected Patients Dan Nguyen-Jean Hsu-Farook Jahoor-Rajagopal Sekhar – http://press.endocrine.org/doi/abs/10.1210/jc.2013-2376
  5. Glutathione dysregulation and the etiology and progression of human diseases Nazzareno Ballatori-Suzanne Krance-Sylvia Notenboom-Shujie Shi-Kim Tieu-Christine Hammond – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756154/
  6. The emerging role of glutathione in Alzheimer’s disease. S Saharan-P Mandal – https://www.ncbi.nlm.nih.gov/pubmed/24496077
  7. Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine Rajagopal Sekhar-Siripoom McKay-Sanjeet Patel-Anuradha Guthikonda-Vasumathi Reddy-Ashok Balasubramanyam-Farook Jahoor – http://care.diabetesjournals.org/content/34/1/162
  8. Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study. O Sendur-Y Turan-E Tastaban-C Yenisey-M Serter – http://www.ncbi.nlm.nih.gov/pubmed/18853166
  9. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. W Dröge-E Holm – http://www.ncbi.nlm.nih.gov/pubmed/9367343
  10. Effect of liver cirrhosis and age on the glutathione concentration in the plasma, erythrocytes, and gastric mucosa of man. C Loguercio-D Taranto-L Vitale-F Beneduce-C Del – http://www.ncbi.nlm.nih.gov/pubmed/8720922
  11. The glutathione defense system in the pathogenesis of rheumatoid arthritis. M Hassan-R Hadi-Z Al-Rawi-V Padron-S Stohs – http://www.ncbi.nlm.nih.gov/pubmed/11180282
  12. Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin resistance in aging Dipali Pathak713-798-4710Houston, TX – Apr 2, 2013 – https://www.bcm.edu/news/geriatrics/glutathione-deficiency-fat-insulin-aging
  13. Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers Jason Allen-Ryan Bradley – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162377/
  14. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. C Lang-B Mills-H Lang-M Liu-W Usui-J Richie-W Mastropaolo-S Murrell – https://www.ncbi.nlm.nih.gov/pubmed/12486409
  15. Age and gender dependent levels of glutathione and glutathione S-transferases in human lymphocytes Esther M.M.van Lieshout and Wilbert H.M.Peters – http://carcin.oxfordjournals.org/content/19/10/1873.full.pdf
  16. Nano Glutathione Diffusion Study Results https://www.nanoceuticalsolutions.com/wp-content/uploads/2016/06/Nano-Glutathione-Drug-Diffususion-Study-Results.pdf

Sources

  1. http://drhyman.com/blog/2012/02/20/how-toxins-make-you-fat-4-steps-to-get-rid-of-toxic-weight/
  2. http://www.fasebj.org/content/13/10/1231.abstract?ijkey=8327018abdff3142c78c682dae57dafddfb5ab59&keytype2=tf_ipsecsha
  3. http://mthfr.net/what-is-mthfr/2011/11/04/
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699736/
  5. http://www.dailytelegraph.com.au/entertainment/why-brad-pitt-injects-himself-and-other-wacky-celebrity-secrets/news-story/faa90e1ab5d8b879aad62fabb5c0a999
  6. http://ajcn.nutrition.org/content/87/6/1939.full